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Receptor variant influences dopamine response to alcohol

Striatum. Images are from Anatomography mainta...

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Researchers showed that human subjects with the 118G variant of the mu-opioid receptor released dopamine from the ventrial┬ástriatum of the brain in response to alcohol, while those with the more common 118A variant of this receptor did not. They then demonstrated that mice carrying the gene for the 118G┬áreceptor variant showed a fourfold higher peak dopamine response to alcohol compared to mice with the 118A receptor variant gene. … > read full article

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