Early Cannabis Use Associated With Poor Brain Function, UK



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Regular cannabis users who start using the drug before the age of 15 perform worse on brain tests than those who start later, according to new research published in the June issue of the British Journal of Psychiatry.

Researchers from the Universidade Federal de Sao Paulo say their study suggests that early cannabis use may have more harmful effects on people’s cognitive functioning.

The researchers asked 104 chronic cannabis users to take part in a series of neuropsychological tasks. These tested their executive functioning, attention, perseverance, ability to form abstract concepts, visual and motor skills, and mental flexibility.

Of the 104 chronic cannabis users, 49 started using the drug before the age of 15 (early-onset users). The remaining 55 started using it after the age of 15 (late-onset users). On average, the early-onset group had used cannabis for 10.9 years – equating to an estimated lifetime consumption of 6,790 joints each. The late-onset group had used cannabis for an average of 8.7 years – equating to 5,160 joints each. Another 44 people who did not use cannabis also took the tests, and acted as the control group.

There were no differences in IQ between the three groups. However, the early-onset group performed significantly worse than the late-onset group and the control group on tasks which tested their sustained attention, impulse control and executive functioning. For example, in a card-sorting test, the early-onset group made more errors than the control group (10 vs 6.44) and completed fewer categories (2.77 vs 3.5). There were no significant differences in performance between the late-onset and control groups.

Lead researcher Dr Maria Fontes said: “We found that early-onset, but not late-onset, chronic cannabis users had deficits in their cognitive functioning. We know that adolescence is a period in which the brain appears to be particularly vulnerable to the neurotoxic effects of cannabis. Brain imaging studies have shown that the brain before the age of 15 is still developing and maturing, so exposure to cannabis during this period may be more harmful and lead to lower mental flexibility. It is possible people who start to use cannabis at a later age may use different neural networks, and be able to compensate for their cognitive deficits more than people who started using cannabis at an earlier stage of brain development.”


Fontes MA, Bolla KI, Cunha PJ, Almeida PP, Jungerman F, Laranjeira RR, Bressan RA and Lacerda ALT. Cannabis use before age 15 and subsequent executive functioning. British Journal of Psychiatry2011; 198:442-447

Royal College of Psychiatrists


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